購(gòu)物車(chē)
幫助
021-54845833/15800441009
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Background: |
Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. |
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Applications: |
WB |
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Name of antibody: |
ITGB3 (Phospho-Tyr785) |
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Immunogen: |
Synthetic peptide of human ITGB3 (Phospho-Tyr785) |
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Full name: |
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) (Phospho-Tyr785) |
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Synonyms： |
GT; CD61; GP3A; BDPLT2; GPIIIa; BDPLT16 |
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SwissProt: |
P05106 |
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WB Predicted band size: |
87 kDa |
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WB Positive control: |
HUVEC cells |
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WB Recommended dilution: |
500-1000 |
