兔抗ACACA(Phospho-Ser79)多克隆抗體

Background:

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.

Applications:

WB

Name of antibody:

ACACA (Phospho-Ser80)

Immunogen:

Synthetic peptide of human ACACA (Phospho-Ser80)

Full name:

acetyl-CoA carboxylase alpha (Phospho-Ser79)

Synonyms：

ACC; ACAC; ACC1; ACCA; ACACAD

SwissProt:

Q13085

WB Predicted band size:

266 kDa

WB Positive control:

293 cells treated with AICAR

WB Recommended dilution:

500-1000