購(gòu)物車
幫助
021-54845833/15800441009
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Fusion protein corresponding to a region derived from 195-308 amino acids of human GDF15 |
技術(shù)規(guī)格
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Full name: |
growth differentiation factor 15 |
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Synonyms: |
PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15 |
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Swissprot: |
Q99988 |
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Gene Accession: |
BC000529 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. |
