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  • 小鼠抗PSMC3單克隆抗體

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    • 品牌 : 通蔚生物
    • 目錄號(hào) : TW11746
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中文名稱(chēng): 小鼠抗PSMC3單克隆抗體

英文名稱(chēng): Anti-PSMC3 mouse monoclonal antibody

別    名: proteasome 26S subunit, ATPase 3; TBP1

相關(guān)類(lèi)別: 一抗

儲(chǔ)    存: 冷凍(-20℃)

宿    主: Mouse

抗    原: PSMC3

反應(yīng)種屬: Human

標(biāo) 記 物: Unconjugate

克隆類(lèi)型: mouse monoclonal

技術(shù)規(guī)格

Background:

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9.

Applications:

WB

Name of antibody:

PSMC3

Immunogen:

Fusion protein of human PSMC3

Full name:

proteasome 26S subunit, ATPase 3

Synonyms:

TBP1

SwissProt:

P17980

WB Predicted band size:

49 KD

WB Positive control:

293T, Hela, HepG2, A431 cell lysates

WB Recommended dilution:

200-1000