兔抗AKT1(Phospho-Ser124) 多克隆抗體

Background:

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival.

Applications:

WB

Name of antibody:

AKT1(Phospho-Ser124)

Immunogen:

Peptide sequence around phosphorylation site of serine 124 (S-G-S(p)-P-S) derived from Human Akt.

Full name:

v-akt murine thymoma viral oncogene homolog 1

Synonyms：

AKT; PKB; RAC; CWS6; PRKBA; PKB-ALPHA; RAC-ALPHA

SwissProt:

P31749

WB Predicted band size:

56 kDa

WB Positive control:

Mouse brain tissue lysates

WB Recommended dilution:

500-1000