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  • DENND1A 抗原(重組蛋白)

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    • 品牌 : 通蔚生物
    • 目錄號(hào) : TW16531
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫存:60
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中文名稱: DENND1A 抗原(重組蛋白)

英文名稱: DENND1A Antigen (Recombinant Protein)

別     名: DENN domain containing 1A; FAM31A; KIAA1608

儲(chǔ)     存: 冷凍(-20℃)

相關(guān)類別: 抗原

概     述

Fusion protein corresponding to a region derived from 360-559 amino acids of human DENND1A

技術(shù)規(guī)格

Full name:

DENN domain containing 1A

Synonyms:

FAM31A; KIAA1608

Swissprot:

Q8TEH3

Gene Accession:

BC039703

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).