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  • CARF 抗原(重組蛋白)

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    • 品牌 : 通蔚生物
    • 目錄號(hào) : TW16874
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫(kù)存:90
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中文名稱:CARF 抗原(重組蛋白)

英文名稱: CARF Antigen (Recombinant Protein)

別       名: calcium responsive transcription factor; ALS2CR8; NYD-SP24

儲(chǔ)       存: 冷凍(-20℃)

相關(guān)類別: 抗原

概  述:

Fusion protein corresponding to C terminal 300 amino acids of human CARF

    
技術(shù)規(guī)格:

Full name:

calcium responsive transcription factor

Synonyms:

ALS2CR8; NYD-SP24

Swissprot:

Q8N187

Gene Accession:

BC033777

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

CARF (calcium-response factor), also known as ALS2CR8 (amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein) or NYD-SP24, is a 725 amino acid nuclear protein. Expressed in a wide variety of tissues with highest expression in the hippocampus, CARF is thought to be a transcription factor that associates with the p53 tumor suppression pathway. CARF cooperates, co-localizes and is co-regulated with ARF, an ADP-ribosylation factor, and, through this interaction, helps to mediate ARF-p53-induced apoptotic signaling. This apoptotic pathway is implicated in cell cycle control, proper cellular development, response to DNA damage and the aging process, suggesting that CARF participates in various events throughout the cell.