中文名稱(chēng):DNTT 抗原(重組蛋白)
英文名稱(chēng): DNTT Antigen (Recombinant Protein)
別 名: DNA nucleotidylexotransferase; TDT
儲(chǔ) 存: 冷凍(-20℃)
相關(guān)類(lèi)別: 抗原
概 述:
Fusion protein corresponding to a region derived from 260-509 amino acids of human DNTT |
Full name: |
DNA nucleotidylexotransferase |
Synonyms: |
TDT |
Swissprot: |
P04053 |
Gene Accession: |
BC012920 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. |