兔抗DCUN1D3多克隆抗體

Background:

Covalent attachment of NEDD8 to cullins, a process called neddylation, results in nuclear cullin accumulation, which promotes cell growth, migration, and transformation. DCUN1D3 inhibits neddylation of cullins by sequestering them to the plasma membrane, thereby promoting cell differentiation. Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane (PubMed:25349211). When overexpressed in transformed cells, may promote mesenchymal to epithelial-like changes and inhibit colony formation in soft agar (PubMed:25349211).

Applications:

ELISA, WB

Name of antibody:

DCUN1D3

Immunogen:

Synthetic peptide corresponding to a region derived from 72-85 amino acids of human DCUN1D3

Full name:

defective in cullin neddylation 1 domain containing 3

Synonyms:

44M2.4; SCCRO3

SwissProt:

Q8IWE4

ELISA Recommended dilution:

5000-10000

WB Predicted band size:

34 kDa

WB Positive control:

LO2,231 and A549 cell lysates

WB Recommended dilution:

200-1000