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中文名稱： 兔抗MAPK8/MAPK9/MAPK10 (phospho-Thr183/Tyr185)多克隆抗體
英文名稱： Anti-MAPK8/MAPK9/MAPK10 (phospho-Thr183/Tyr185) rabbit polyclonal antibody
別 名： Stress-activated protein kinase JNK1; c-Jun N-terminal kinase 1; JNK-46
相關(guān)類別： 一抗
儲(chǔ) 存： 冷凍（-20℃） 避光
宿 主： Rabbit
抗 原： MAPK8/MAPK9/MAPK10 (phospho-Thr183/Tyr185)
反應(yīng)種屬： Human, Mouse, Rat
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells By similarity. Phosphorylates heat shock factor protein 4 (HSF4). /Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. JNK2 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it. |
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Applications: |
WB, IF |
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Name of antibody: |
MAPK8/MAPK9/MAPK10 (phospho-Thr183/Tyr185) |
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Immunogen: |
Synthetic peptide of human MAPK8/MAPK9/MAPK10 (phospho-Thr183/Tyr185) |
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Full name: |
MAPK8/MAPK9/MAPK10 (phospho-Thr183/Tyr185) |
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Synonyms： |
Stress-activated protein kinase JNK1 ; c-Jun N-terminal kinase 1; JNK-46 |
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SwissProt: |
P45983/P45984/P53779 |
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WB Predicted band size: |
46 kDa; 54 kDa |
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WB Positive control: |
C6 cells treated with anisomycin |
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WB Recommended dilution: |
500-1000 |
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IF Positive control: |
Hela cells |
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IF Recommended dilution |
100-200 |
