兔抗ALOX5多克隆抗體

Background:

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, IHC

Name of antibody:

ALOX5

Immunogen:

Fusion protein of human ALOX5

Full name:

Arachidonate 5-lipoxygenase

Synonyms：

5-LO, 5LPG, LOG5, 5-LOX

SwissProt:

P09917

ELISA Recommended dilution:

500-5000

IHC positive control:

Human colon cancer and human thyroid cancer

IHC Recommend dilution:

50-150