兔抗DDIT4多克隆抗體

Background:

REDD-1, also designated DNA-damage-inducible transcript 4, dig2 or RTP801, is thought to function in the regulation of reactive oxygen species (ROS). REDD-1 expression has also been linked to apoptosis, Ab toxicity and the pathogenesis of ischemic diseases. As an HIF-1-responsive gene, REDD-1 exhibits strong hypoxia-dependent upregulation in ischemic cells of neuronal origin. In response to stress due to DNA damage and glucocorticoid treatment, REDD-1 is upregulated at the transcriptional level. REDD-1 negatively regulates the mammalian target of Rapamycin (mTOR), a serine/threonine kinase often referred to as FRAP. It is crucial in the coupling of extra- and intracellular cues to FRAP regulation. The absence of REDD-1 is associated with the development of retinopathy, a major cause of blindness.

Applications:

ELISA, IHC

Name of antibody:

DDIT4

Immunogen:

Fusion protein of human DDIT4

Full name:

DNA-damage-inducible transcript 4

Synonyms：

Dig2; REDD1; REDD-1

SwissProt:

Q9NX09

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human liver cancer and human gastric cancer

IHC Recommend dilution:

50-200