兔抗DDR1(Ab-796) 多克隆抗體

Background:

Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing By similarity. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.

Applications:

WB

Name of antibody:

DDR1(Ab-796)

Immunogen:

Synthesized non-phosphopeptide derived from human DDR1 around the phosphorylation site of tyrosine 796.

Full name:

discoidin domain receptor tyrosine kinase 1

Synonyms：

CAK; DDR; NEP; HGK2; PTK3; RTK6; TRKE; CD167; EDDR1; MCK10; NTRK4; PTK3A

SwissProt:

Q08345

WB Predicted band size:

101 kDa

WB Positive control:

Jurkat cells lysates

WB Recommended dilution:

500-3000