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  • IQGAP3抗原(重組蛋白)

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    • 品牌 : 通蔚生物
    • 目錄號 : TW18002
    • 應用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
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中文名稱:IQGAP3抗原(重組蛋白)

英文名稱 IQGAP3 Antigen (Recombinant Protein)

儲      存: 冷凍(-20℃)

相關類別 抗原

概述

Fusion protein corresponding to a region derived from 1165-1325 amino acids of human IQGAP3


技術規(guī)格

Full name:

IQ motif containing GTPase activating protein 3

Swissprot:

Q86VI3

Gene Accession:

BC131536

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

IQGAP3 (IQ motif containing GTPase activating protein 3) is a 1,631 amino acid protein that acts as an effector of Cdc42 and Rac 1, linking their activation to the cytoskeleton during neuronal morphogenesis. A novel member of the IQGAP family, IQGAP3 is highly expressed in brain where it localizes to axons of hippocampal neurons. IQGAP3 contains one Ras-GAP domain, a CH (calponin-homology) domain, four IQ domains and is encoded by a gene located on human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.