中文名稱:GMDS抗原(重組蛋白)
英文名稱: GMDS Antigen (Recombinant Protein)
別 名: GMD; SDR3E1
儲(chǔ) 存: 冷凍(-20℃)
相關(guān)類別: 抗原
概 述:
Fusion protein corresponding to a region derived from 173-372 amino acids of human GMDS |
Full name: |
GDP-mannose 4,6-dehydratase |
Synonyms: |
GMD; SDR3E1 |
Swissprot: |
O60547 |
Gene Accession: |
BC000117 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020). |