購(gòu)物車
幫助
021-54845833/15800441009
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Background: |
Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
DSP |
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Immunogen: |
Synthetic peptide of human DSP |
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Full name: |
desmoplakin |
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Synonyms： |
DP; DPI; DPII |
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SwissProt: |
P15924 |
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ELISA Recommended dilution: |
1000-2000 |
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IHC positive control: |
Human breast cancer and Human brain |
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IHC Recommend dilution: |
25-100 |
