中文名稱: 兔抗MLKL多克隆抗體
英文名稱: Anti-MLKL rabbit polyclonal antibody
別 名: mixed lineage kinase domain like pseudokinase; hMLKL
相關(guān)類別: 一抗
儲(chǔ) 存: 冷凍(-20℃)
宿 主: Rabbit
抗 原: MLKL
反應(yīng)種屬: Human
標(biāo) 記 物: Unconjugate
克隆類型: rabbit polyclonal
技術(shù)規(guī)格
Background: |
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. |
Applications: |
ELISA, IHC |
Name of antibody: |
MLKL |
Immunogen: |
Fusion protein of human MLKL |
Full name: |
mixed lineage kinase domain like pseudokinase |
Synonyms: |
hMLKL |
SwissProt: |
Q8NB16 |
ELISA Recommended dilution: |
5000-10000 |
IHC positive control: |
Human liver cancer and Human tonsil |
IHC Recommend dilution: |
50-300 |