兔抗ANLN多克隆抗體

Background:

Anillin, also known as scraps homolog, is an evolutionarily conserved Actin- binding protein required for cytokinesis that was first identified in Drosophila melanogaster. Anillin is a ubiquitously expressed protein with highest expression levels in the central nervous system. It is predominantly found in the nucleus and it localizes to the cleavage furrow during cytokinesis, forming a ring with the help of Rac GTPase. During cytokinesis, Anillin interacts with CD2AP and functions to concentrate Rho A and maintain the localization of active Myosin. In Anillin knockout cells the cleavage furrow fails to complete ingression. Anillin expression levels fluctuate with the cell cycle, peaking in mitosis.

Applications:

ELISA, IHC

Name of antibody:

ANLN

Immunogen:

Fusion protein of human ANLN

Full name:

anillin, actin binding protein

Synonyms：

scra; Scraps

SwissProt:

Q9NQW6

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human brain

IHC Recommend dilution:

25-100