兔抗RPS6KA1(Phospho-Thr573) 多克隆抗體

Background:

Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes.

Applications:

WB, IHC

Name of antibody:

RPS6KA1(Phospho-Thr573)

Immunogen:

Peptide sequence around phosphorylation site of threonine 573(L-M-T(p)-P-C) derived from Human p90 RSK.

Full name:

ribosomal protein S6 kinase, 90kDa, polypeptide 1

Synonyms：

RSK; HU-1; RSK1; MAPKAPK1A

SwissProt:

Q15418

IHC positive control:

Human breast carcinoma tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

83 kDa

WB Positive control:

293 cells lysates treated with UV

WB Recommended dilution:

500-1000