兔抗PITX2多克隆抗體

Background:

This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Applications:

ELISA, WB

Name of antibody:

PITX2

Immunogen:

Fusion protein of human PITX2

Full name:

paired-like homeodomain 2

Synonyms：

RS; RGS; ARP1; Brx1; IDG2; IGDS; IHG2; PTX2; RIEG; IGDS2; IRID2; Otlx2; RIEG1

SwissProt:

Q99697

ELISA Recommended dilution:

2000-5000

WB Predicted band size:

35 kDa

WB Positive control:

HepG2 cells

WB Recommended dilution:

500-2000