中文名稱: 兔抗PTEN (Phospho-Ser380/Thr382/Thr383)多克隆抗體
英文名稱: Anti-PTEN (Phospho-Ser380/Thr382/Thr383) rabbit polyclonal antibody
別 名: BZS; DEC; CWS1; GLM2; MHAM; TEP1; MMAC1; PTEN1; 10q23del
相關(guān)類別: 一抗
儲 存: 冷凍(-20℃) 避光
宿 主: Rabbit
反應種屬: Human, Mouse, Rat
標 記 物: Unconjugate
克隆類型: rabbit polyclonal
抗 原: PTEN (Phospho-Ser380/Thr382/Thr383)
技術(shù)規(guī)格
Background: |
Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. |
Applications: |
WB, IHC, IF |
Name of antibody: |
PTEN (Phospho-Ser380/Thr382/Thr383) |
Immunogen: |
Synthetic peptide of human PTEN (Phospho-Ser380/Thr382/Thr383) |
Full name: |
phosphatase and tensin homolog (Phospho-Ser380/Thr382/Thr383) |
Synonyms: |
BZS; DEC; CWS1; GLM2; MHAM; TEP1; MMAC1; PTEN1; 10q23del |
SwissProt: |
P60484 |
IHC positive control: |
Human breast carcinoma |
IHC Recommend dilution: |
50-100 |
WB Predicted band size: |
54 kDa |
WB Positive control: |
Hela cells |
WB Recommended dilution: |
500-1000 |
IF Positive control: |
Hela cells |
IF Recommended dilution |
100-200 |