兔抗GSK3A/B多克隆抗體

Background:

GSK3A encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. GSK3B is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease.

Applications:

WB

Name of antibody:

GSK3A/B

Immunogen:

Synthetic peptide of human GSK3A/B

Full name:

glycogen synthase kinase 3 alpha/beta

SwissProt:

P49840/ P49841

WB Predicted band size:

51/47 kDa

WB Positive control:

TNF-a treated 293 whole cell lysates

WB Recommended dilution:

500-1000