兔抗SMG8多克隆抗體

Background:

Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity.

Applications:

ELISA, WB

Name of antibody:

SMG8

Immunogen:

Synthetic peptide of human SMG8

Full name:

SMG8, nonsense mediated mRNA decay factor

Synonyms:

C17orf71

SwissProt:

Q8ND04

ELISA Recommended dilution:

5000-10000

WB Predicted band size:

110 kDa

WB Positive control:

TM4 cell lysate

WB Recommended dilution:

200-1000