兔抗BCAR1(Phospho-Tyr410)多克隆抗體

Background:

BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion. Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.

Applications:

WB, IHC

Name of antibody:

BCAR1(Phospho-Tyr410)

Immunogen:

Peptide sequence around phosphorylation site of tyrosine 410(G-V-Y(p)-A-V) derived from Human p130 Cas .

Full name:

breast cancer anti-estrogen resistance 1

Synonyms：

CAS; CAS1; CASS1; CRKAS; P130Cas

SwissProt:

P56945

IHC positive control:

Human breast carcinoma tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

93 kDa

WB Positive control:

K562 cells and NIH/3T3 cells lysates

WB Recommended dilution:

500-1000