兔抗CCDC88A(Phospho-Ser1417)多克隆抗體

Background:

This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Applications:

IHC

Name of antibody:

CCDC88A(Phospho-Ser1417)

Immunogen:

Peptide sequence around phosphorylation site of Serine 417(L-E-M(p)-A-Q) derived from Human Girdin .

Full name:

coiled-coil domain containing 88A

Synonyms：

APE; GIV; GRDN; HkRP1; GIRDIN; KIAA1212

SwissProt:

Q3V6T2

IHC positive control:

Human breast carcinoma tissue

IHC Recommend dilution:

50-100