兔抗WRN多克隆抗體

Background:

This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.

Applications:

ELISA, IHC

Name of antibody:

WRN

Immunogen:

Synthetic peptide of human WRN

Full name:

Werner syndrome RecQ like helicase

Synonyms:

RECQ3; RECQL2; RECQL3

SwissProt:

Q14191

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer and human lung cancer

IHC Recommend dilution:

25-100