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  • ULK4 抗原(重組蛋白)

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    • 品牌 : 通蔚生物
    • 目錄號(hào) : TW6241
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
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中文名稱: UNC13B 抗原(重組蛋白)

英文名稱 UNC13B Antigen (Recombinant Protein)

別     名: unc-13 homolog B; UNC13; MUNC13; Unc13h2; munc13-2

相關(guān)類別:抗原

儲(chǔ)     存: 冷凍(-20℃)

概     述

Fusion protein corresponding to a region derived from 1411-1610 amino acids of human UNC13B

技術(shù)規(guī)格

Full name:

unc-13 homolog B

Synonyms:

UNC13; MUNC13; Unc13h2; munc13-2

Swissprot:

O14795

Gene Accession:

BC111781

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.