購(gòu)物車(chē)
幫助
021-54845833/15800441009
中文名稱(chēng)：AIFM1抗原（重組蛋白）
英文名稱(chēng)：AIFM1 Antigen (Recombinant Protein)
儲(chǔ) 存：冷凍（-20℃）
相關(guān)類(lèi)別：抗原
概述
Fusion protein corresponding to C terminal 250 amino acids of human AIFM1
技術(shù)規(guī)格
Full name:
apoptosis-inducing factor, mitochondrion-associated, 1
Synonyms:
AIF, PDCD8, COXPD6
Swissprot:
O95831
Gene Accession:
BC139738
Purity:
>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:
Escherichia coli
Tags:
His tag C-Terminus, GST tag N-Terminus
Background:
This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10.
