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  • 兔抗MACROD1多克隆抗體

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    • 品牌 : 通蔚生物
    • 目錄號 : TW11680
    • 應用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
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中文名稱: 兔抗MACROD1多克隆抗體  

英文名稱: Anti-MACROD1 rabbit polyclonal antibody

別    名: mono-ADP ribosylhydrolase 1; LRP16

相關類別: 一抗

儲    存: 冷凍(-20℃)

宿    主: Rabbit

抗    原: MACROD1

反應種屬: Human, Mouse, Rat

標 記 物: Unconjugate

克隆類型: rabbit polyclonal

技術規(guī)格

Background:

Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474714, PubMed:23474712). Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474714, PubMed:23474712). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21257746). Plays a role in estrogen signaling (PubMed:17893710, PubMed:17914104, PubMed:19403568). Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen (PubMed:19022849). May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation (PubMed:17893710, PubMed:17914104). Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction (PubMed:17914104). Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells (PubMed:17893710). Enhances ESR1-mediated transcription activity (PubMed:17914104).

Applications:

ELISA, IHC

Name of antibody:

MACROD1

Immunogen:

Fusion protein of human MACROD1

Full name:

mono-ADP ribosylhydrolase 1

Synonyms:

LRP16

SwissProt:

Q9BQ69

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human breast cancer and Human thyroid cancer

IHC Recommend dilution:

100-300