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  • 小鼠抗OTUD7B單克隆抗體

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    • 品牌 : 通蔚生物
    • 目錄號(hào) : TW12318
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫(kù)存：20
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中文名稱(chēng)： 小鼠抗OTUD7B單克隆抗體

英文名稱(chēng)： Anti-OTUD7B mouse monoclonal antibody

別    名： OTU deubiquitinase 7B; ZA20D1; CEZANNE

相關(guān)類(lèi)別： 一抗

儲(chǔ)    存： 冷凍（-20℃）

宿    主： Mouse

抗    原： OTUD7B

反應(yīng)種屬： Human

標(biāo) 記 物： Unconjugate

克隆類(lèi)型： mouse monoclonal

技術(shù)規(guī)格

Background:

Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin.

Applications:

WB

Name of antibody:

OTUD7B

Immunogen:

Fusion protein of human OTUD7B

Full name:

OTU deubiquitinase 7B

Synonyms:

ZA20D1; CEZANNE

SwissProt:

Q6GQQ9

WB Predicted band size:

93 KD

WB Positive control:

K562, NCI-H460, PC3 cell lysates

WB Recommended dilution:

500-2000