小鼠抗PCSK9單克隆抗體

Background:

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.

Applications:

WB

Name of antibody:

PCSK9

Immunogen:

Fusion protein of human PCSK9

Full name:

proprotein convertase subtilisin/kexin type 9

Synonyms:

FH3; PC9; NARC1; LDLCQ1; NARC-1; HCHOLA3

SwissProt:

Q8NBP7

WB Predicted band size:

74 KD

WB Positive control:

HepG2, A431 cell lysates

WB Recommended dilution:

200-1000