購物車
幫助
021-54845833/15800441009
中文名稱： AURKAIP1抗原（重組蛋白）
英文名稱： AURKAIP1 Antigen (Recombinant Protein)
別 名： AIP; AKIP; MRP-S38
儲 存： 冷凍（-20℃）
相關(guān)類別： 抗原
概 述
|
Full name: |
aurora kinase A interacting protein 1 |
|
Synonyms: |
AIP; AKIP; MRP-S38 |
|
Swissprot: |
Q9NWT8 |
|
Gene Accession: |
BC062333 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
AKIP (AURKA-interacting protein), also known as AURKAIP1 (aurora kinase A interacting protein 1) or AIP, is a 199 amino acid protein that localizes to the nucleus and is ubiquitously expressed, with highest levels present in testis, heart and skeletal muscle. Interacting specifically with ARK-1 (aurora kinase 1), AKIP functions to induce the proteasomal-dependent degradation of ARK-1, thereby acting as a negative regulator of ARK-1 activity. AKIP is encoded by a gene which maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma. |
