兔抗CTTN多克隆抗體

Background:

Cortactin is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene.

Applications:

WB, IHC

Name of antibody:

CTTN

Immunogen:

Synthetic peptide of human CTTN (Ab-466)

Full name:

cortactin

Synonyms：

Amplaxin; CTTN; EMS1; SRC8

SwissProt:

Q14247

IHC positive control:

Human breast carcinoma

IHC Recommend dilution:

50-100

WB Predicted band size:

85 kDa

WB Positive control:

3T3 and C2C12 cells

WB Recommended dilution:

500-1000