兔抗CYFIP2多克隆抗體

Background:

CYFIP2 (Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121) is a 1,278 amino acid protein encoded by the human gene CYFIP2. CYFIP2 belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis. It interacts with FMR1, FXR1 and FXR2 and is a component of the WAVE1 complex composed of Abi-2, CYFIP2, C3orf10/HSPC300, NAP125 and WASF1/WAVE1. Upon binding to activated Rac 1, CYFIP2 causes the complex to dissociate, releasing activated WASF1. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter. Induced expression of CYFIP2 is sufficient for caspase activation and cellular apoptosis, reminiscent of p53 activation.

Applications:

ELISA, WB, IHC

Name of antibody:

CYFIP2

Immunogen:

Fusion protein of human CYFIP2

Full name:

cytoplasmic FMR1 interacting protein 2

Synonyms：

PIR121

SwissProt:

Q96F07

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human liver cancer and human gastric cancer

IHC Recommend dilution:

50-200

WB Predicted band size:

148 kDa

WB Positive control:

Mouse brain and human fetal brain tissue

WB Recommended dilution:

500-2000