兔抗DEPTOR多克隆抗體

Background:

DEPTOR (DEP domain containing MTOR-interacting protein), also known as DEP.6 or DEPDC6 (DEP domain-containing protein 6), is a 409 amino acid protein that negatively regulates mTORC1 and mTORC2 pathways. DEPTOR interacts with FRAP via its PDZ domain, and undergoes post-translational phosphorylation. Containing two DEP domains and one PDZ (DHR) domain, DEPTOR is encoded by a gene that maps to human chromosome 8q24.12. Chromosome 8 consists of nearly 146 million base pairs, encodes over 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that map to chromosome 8.

Applications:

ELISA, WB, IHC

Name of antibody:

DEPTOR

Immunogen:

Synthetic peptide of human DEPTOR

Full name:

DEP domain containing MTOR-interacting protein

Synonyms:

DEP.6; DEPDC6

SwissProt:

Q8TB45

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human thyroid cancer;Human liver cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

46 kDa

WB Positive control:

Human fetal liver tissue lysate

WB Recommended dilution:

200-1000