兔抗EID3多克隆抗體

Background:

EID3 is highly expressed in testis and shows homology to a region of EID1 implicated in binding to CBP/p300. EID3 acts as a potent inhibitor of nuclear receptor transcriptional activity by a mechanism that is independent of direct interactions with nuclear receptors, including SHP. Furthermore, EID3 directly binds to and blocks the SRC-1 interacting domain of CBP, which has been implicated to act as the interaction surface for nuclear receptor co-activators. Consistent with this idea, EID3 prevents recruitment of CBP to a natural nuclear receptor-regulated promoter.

Applications:

ELISA, IHC

Name of antibody:

EID3

Immunogen:

Synthetic peptide of human EID3

Full name:

EP300 interacting inhibitor of differentiation 3

Synonyms:

NS4EB; NSE4B; NSMCE4B

SwissProt:

Q8N140

IHC positive control:

Human gastric cancer and human thyroid cancer

IHC Recommend dilution:

25-100