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  • TPPP抗原（重組蛋白）

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    • 品牌 : 通蔚生物
    • 目錄號 : TW19992
    • 應用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫存：60
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中文名稱： TPPP抗原（重組蛋白）

英文名稱： TPPP Antigen (Recombinant Protein)

別     名：  p24; p25; TPPP1; TPPP/p25; p25alpha

儲     存：  冷凍（-20℃）

相關類別： 抗原

概     述

Full length fusion protein

技術規(guī)格

Full name:

tubulin polymerization promoting protein

Synonyms:

p24; p25; TPPP1; TPPP/p25; p25alpha

Swissprot:

O94811

Gene Accession:

BC131506

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Tubulin family members are globular proteins important in the assembly of microtubules. Microtubules are structural components that play important roles in mitosis, cytokinesis and vesicle transport. TPPP (Tubulin polymerization-promoting protein), also known as p24 and p25, is a widely expressed 219 amino acid protein found in the perinuclear region of the cytoplasm. TPPP may form dimers and functions in polymerizing tubulin into double-walled tubules, polymorphic aggregates, or stabilized blocks. TPPP overexpression prevents formation of the mitotic spindle assembly and breakdown of the nuclear envelope. TPPP is phosphorylated by TPK II and is encoded by a gene that maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown.