兔抗F7多克隆抗體

Background:

This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Applications:

ELISA, IHC

Name of antibody:

F7

Immunogen:

Fusion protein of human F7

Full name:

coagulation factor VII (serum prothrombin conversion accelerator)

Synonyms：

SPCA

SwissProt:

P08709

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human thyroid cancer and human lung cancer

IHC Recommend dilution:

15-50