兔抗SELENOS多克隆抗體

Background:

This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion. An alternatively spliced transcript variant, lacking the SECIS element and encoding a non-Sec containing shorter isoform, has been described for this gene (PMID:23614019). [provided by RefSeq, Jul 2017]

Applications:

ELISA, IHC

Name of antibody:

SELENOS

Immunogen:

Synthetic peptide of human SELENOS

Full name:

selenoprotein S

Synonyms:

SELS; VIMP; ADO15; SBBI8; SEPS1; AD-015

SwissProt:

Q9BQE4

IHC positive control:

Human brain and Human renal cancer

IHC Recommend dilution:

25-100