兔抗NXF1多克隆抗體

Background:

This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants.

Applications:

WB

Name of antibody:

NXF1

Immunogen:

Synthesized peptide derived from N-terminal of human NXF1.

Full name:

nuclear RNA export factor 1

Synonyms：

TAP; MEX67

SwissProt:

Q9UBU9

WB Predicted band size:

70 kDa

WB Positive control:

HepG2 cells, Jurkat cells and Hela cells lysates

WB Recommended dilution:

500-3000