兔抗PIK3R3多克隆抗體

Background:

Phosphatidylinositol 3-kinase is a lipid kinase that phosphorylates the inositol ring of phosphatidylinositol and related compounds at the 3’ position. PI 3-kinase p55 (PIK3R3) is comprised of a catalytic subunit and a regulatory subunit. The human p55 protein is composed of a rare amino terminal region followed by a proline-rich motif and two Src homology 2 (SH2) domains. PI 3-kinase p55 mRNAs are expressed in most human fetal and adult tissues; predominant expression is observed in the adult testis. Splice variant(s) of PI 3-kinase p55 have been identified; one of which has a deletion of 36 amino acids at the amino terminus and another which has an insertion of 59 amino acids at position 256 between the SH2 domains. Research suggests that PI 3-kinase p55 interacts with the IGFIR (Insulin-like growth factor-I receptor) and IR (Insulin receptor) and may be involved in PI 3-kinase activation by these receptors.

Applications:

ELISA, WB, IHC

Name of antibody:

PIK3R3

Immunogen:

Synthetic peptide of human PIK3R3

Full name:

phosphoinositide-3-kinase, regulatory subunit 3 (gamma)

Synonyms：

p55; p55-GAMMA

SwissProt:

Q92569

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human lung cancer and Human gastric cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

54 kDa

WB Positive control:

Mouse brain, human fetal brain and mouse testis tissue, hela cells and human fetal kidney tissue

WB Recommended dilution:

500-2000