兔抗PSMC4多克隆抗體

Background:

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Applications:

ELISA, IHC

Name of antibody:

PSMC4

Immunogen:

Fusion protein of human PSMC4

Full name:

proteasome 26S subunit, ATPase 4

Synonyms:

S6; RPT3; TBP7; TBP-7; MIP224

SwissProt:

P43686

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human esophagus cancer;

IHC Recommend dilution:

30-150