購物車
幫助
021-54845833/15800441009
中文名稱： 兔抗TRIM71多克隆抗體
英文名稱： Anti-TRIM71 rabbit polyclonal antibody
別 名： LIN41; LIN-41
相關(guān)類別： 一抗
儲 存： 冷凍（-20℃）
宿 主： Rabbit
抗 原： TRIM71
反應(yīng)種屬： Human, Mouse, Rat
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
TRIM71 is the mammalian ortholog to the C. elegans heterochronic protein Lin41, a protein that is thought to be important in postembryonic development , and is genetically and biochemically downstream of both Shh and Fgf signaling pathways. Similar to its C. elegans homolog, TRIM71 is a target of the microRNA let-7 and is likely to play a role in mammalian development. Recent experiments have indicated that TRIM71 is an E3 ubiquitin ligase and can interact with the Dicer and the Argonaute proteins Ago1, Ago2, and Ago4. Overexpression and depletion of TRIM71 led to inverse changes in Ago2 protein levels, suggesting TRIM71 can regulate Ago2 turnover. Finally, TRIM71 cooperates with the pluripotency factor Lin-28 in regulating let-7. May be involved in controlling the timing of organ formation during development. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
TRIM71 |
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Immunogen: |
Synthetic peptide of human TRIM71 |
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Full name: |
tripartite motif containing 71, E3 ubiquitin protein ligase |
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Synonyms: |
LIN41; LIN-41 |
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SwissProt: |
Q2Q1W2 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human liver cancer and human esophagus cancer |
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IHC Recommend dilution: |
25-100 |
