兔抗SUV39H2多克隆抗體

Background:

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.

Applications:

ELISA, WB, IHC

Name of antibody:

SUV39H2

Immunogen:

Fusion protein of human SUV39H2

Full name:

suppressor of variegation 3-9 homolog 2

Synonyms:

KMT1B

WB Recommended dilution:

500-2000

WB Positive control:

293T and K562 cell lysates

WB Predicted band size:

47 kDa

IHC Recommend dilution:

50-200

IHC positive control:

Human prostate cancer

ELISA Recommended dilution:

5000-10000

SwissProt:

Q9H5I1