兔抗Baz2a多克隆抗體

Background:

Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing By similarity.

Applications:

WB

Name of antibody:

Baz2a

Immunogen:

Synthesized peptide derived from internal of human BAZ2A.

Full name:

bromodomain adjacent to zinc finger domain, 2A

Synonyms：

TIP5; WALp3

SwissProt:

Q9UIF9

WB Predicted band size:

211 kDa

WB Positive control:

Jurkat cells lysate

WB Recommended dilution:

500-3000