兔抗BIN1多克隆抗體

Background:

This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.

Applications:

ELISA, WB

Name of antibody:

BIN1

Immunogen:

Fusion protein of human BIN1

Full name:

bridging integrator 1

Synonyms：

AMPH2; AMPHL; SH3P9

SwissProt:

O00499

ELISA Recommended dilution:

1000-2000

WB Predicted band size:

65 kDa

WB Positive control:

Raji cells

WB Recommended dilution:

200-1000