兔抗CCR5多克隆抗體

Background:

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation.

Applications:

ELISA, IHC

Name of antibody:

CCR5

Immunogen:

Synthetic peptide of human CCR5

Full name:

chemokine (C-C motif) receptor 5 (gene/pseudogene)

Synonyms：

CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5

SwissProt:

P51681

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human Lymphoma and Human liver cancer

IHC Recommend dilution:

25-100