購(gòu)物車(chē)
幫助
021-54845833/15800441009
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Background: |
Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. |
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Applications: |
WB, IF |
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Name of antibody: |
KSR2 |
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Immunogen: |
Synthesized peptide derived from internal of human KSR2. |
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Full name: |
kinase suppressor of ras 2 |
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Synonyms： |
0 |
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SwissProt: |
Q6VAB6 |
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WB Predicted band size: |
108 kDa |
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WB Positive control: |
COS7,293,3T3 cell lysates |
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WB Recommended dilution: |
500-3000 |
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IF positive control: |
Hela cells |
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IF Recommend dilution: |
100-500 |
