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  • NARF抗原（重組蛋白）

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    • 品牌 : 通蔚生物
    • 目錄號(hào) : TW17615
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫(kù)存：40
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中文名稱：NARF抗原（重組蛋白）

英文名稱： NARF Antigen (Recombinant Protein)

別       名： nuclear prelamin A recognition factor; IOP2

儲(chǔ)       存： 冷凍（-20℃）
相關(guān)類別： 抗原

概述

Fusion protein corresponding to a region derived from 257-456 amino acids of human NARF

技術(shù)規(guī)格

Full name:

nuclear prelamin A recognition factor

Synonyms:

IOP2

Swissprot:

Q9UHQ1

Gene Accession:

BC016440

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing.