兔抗F10多克隆抗體

Background:

This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity.

Applications:

ELISA, WB

Name of antibody:

F10

Immunogen:

Fusion protein of human F10

Full name:

Coagulation factor X

Synonyms：

FX; FXA

SwissProt:

P00742

ELISA Recommended dilution:

1000-2000

WB Predicted band size:

55 kDa

WB Positive control:

A549 cells

WB Recommended dilution:

200-1000